At the base of the channel is the methyltransfer pore, which connects the pocket to the AdoMet-binding cleft. Naturally, people obtain enough Lysine from foods, however athletes, vegans, and individuals who don’t like beans might have more.

The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and which are structurally not related to SET-domain proteins four - 6 Recent work suggests that SET-area-containing proteins methylate a couple of proteins along with histones (see later)